Self-organization is a process in which local interaction between components of a system spontaneously produce ordered structures and fascinating patterns which exhibit emergent functions in the absence of a professional designer. This is a common assembly process in a biosystem and can be co-opted by scientists and designers based on different construction principles and logics of design. Since self-organization grants several advantages to the system including robustness, flexibility and adaptability to the surrounding environment, innovations based on this self-organization may provide a unique avenue for designers and inventors.
Biomaterials: Cytoskeletons & Motor proteins
The study of self-organization in a biosystem, a system comprised of skeletons in cells so-called as cytoskeleton (microtubules and actin) and its related motor proteins, provides one with unique tools and design principles not seen in other systems. The biosystem is one of the best candidates for innovation since they autonomously form various structures, and determine the morphology of the cell wherein they lie. This allows a designer with the ability to innovate with these self-assembling structures, potentially bringing this microscopic design into the macroscopic world. We are studying it using the reconstituted system of cytoskeleton combining with micro/nanotechnologies.
Interior, Architecture design
To explore potential applications of self-organization, our other challenge is to develop artificial systems organized through self-organization at human scales inspired by cytoskeletons.
Basic Equipments & technologies
Nikon Ti2-E, Epi-fluorescence microscope
Fluorescence microscopy imaging
Optline TIRF ReLIEF
A total internal reflection fluorescence microscope to observe thin region of a specimen, usually less than 200 nanometers
Atomic force microscope to visualize surface molecular structure of materials at nm resolution
3D print at high resolution (0.025 mm) using Low Force Stereolithography (LFS)
Cover art & BIOART Gallery
In Vitro Synthesis and Design of Kinesin Biomolecular Motors by Cell-Free Protein Synthesis
Inoue, D.; Ohashi, K.; Takasuka, E. T.; Kakugo, A.
Self-repair protects microtubules from destruction by molecular motors
Triclin S.†, Inoue D.†, Gaillard J., Htet Z. M., DeSantis M. E., Portran D., Derivery E., Aumeier C., Schaedel L., John K., Leterrier C., Reck-Peterson S. L., Blanchoin L.* & Théry M.* (†Contribution equal)