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CytoArchitec lab

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  • Self-Organization
  • Basic technologies
  • Art gallery
  • Cover Gallery
  • ギャラリー
  • Selected papers
  • Free Materials
  • Member
  • Contact
  • ソーシャルフィード
  • Related labs
  • …  
    • Home
    • Self-Organization
    • Basic technologies
    • Art gallery
    • Cover Gallery
    • ギャラリー
    • Selected papers
    • Free Materials
    • Member
    • Contact
    • ソーシャルフィード
    • Related labs

    CytoArchitec lab

    • Home
    • Self-Organization
    • Basic technologies
    • Art gallery
    • Cover Gallery
    • ギャラリー
    • Selected papers
    • Free Materials
    • Member
    • Contact
    • ソーシャルフィード
    • Related labs
    • …  
      • Home
      • Self-Organization
      • Basic technologies
      • Art gallery
      • Cover Gallery
      • ギャラリー
      • Selected papers
      • Free Materials
      • Member
      • Contact
      • ソーシャルフィード
      • Related labs
      • Kyushu University, Faculty of Design

        Cytoskeletal Architecture

        and

        Bio-Self-Assembly lab

      • Design inspired by self-organization in biosystem

        Self-organization is a process in which local interaction between components of a system spontaneously produce ordered structures and fascinating patterns which exhibit emergent functions in the absence of a professional designer. This is a common assembly process in a biosystem and can be co-opted by scientists and designers based on different construction principles and logics of design. Since self-organization grants several advantages to the system including robustness, flexibility and adaptability to the surrounding environment, innovations based on this self-organization may provide a unique avenue for designers and inventors.

        Biomaterials: Cytoskeletons & Motor proteins

        Biophysics, Micro/Nanotechnology

        The study of self-organization in a biosystem, a system comprised of skeletons in cells so-called as cytoskeleton (microtubules and actin) and its related motor proteins, provides one with unique tools and design principles not seen in other systems. The biosystem is one of the best candidates for innovation since they autonomously form various structures, and determine the morphology of the cell wherein they lie. This allows a designer with the ability to innovate with these self-assembling structures, potentially bringing this microscopic design into the macroscopic world. We are studying it using the reconstituted system of cytoskeleton combining with micro/nanotechnologies.

        Artificial materials

        Interior, Architecture design

        To explore potential applications of self-organization, our other challenge is to develop artificial systems organized through self-organization at human scales inspired by cytoskeletons.

      • Basic Equipments & technologies

        Nikon Ti2-E,
        Epi-fluorescence microscope

        Fluorescence microscopy imaging and Label-free imaging with interference reflection microscopy (IRM)

        Formlabs Form3,

        3D printer

        3D print at high resolution
        (0.025 mm) using Low Force Stereolithography (LFS)

      • Cover art & BIOART Gallery

      • a
      • Toilet paper indicates actin filaments polymerizing at cell front. Smou wrestler is myosin.
        ZIgzag pattern of gliding microtubules formed under cyclic stretching
        Active nematic of taxol stabilized microtubules polymerized by GTP
        RIng-shaped microtubule assemblies
        Gliding microtubules over kinesin coated surface observed by IRM
        Steampunk Molecular Chaperone, prototype
        Steampunk Molecular Chaperone, prototype
        Motility assay of 3D printed Steampunk Dynein along tubulin protofilament
        3D printing by using Silk Worm
        ACT48 drawn by Midjourney AI
      • Selected Papers

        Design X Bioinformatics: a community-driven initiative to connect bioinformatics and design

        Sommer, B.*; Inoue, D.; Baaden, M.

        Journal of Integrative Bioinformatics,2022,19

        Monopolar flocking of microtubules
        in collective motion

        Afroze, F.†; Inoue, D.†; Farhana, T. I.; Hiraiwa, T.; Akiyama, R.; Kabir A. M. R.; Sada, K.; Kakugo, A.*
        (†Contribution equal)

        Biochemical and Biophysical Research Communications 2021, 563,73-78

        Self-repair protects microtubules from destruction by molecular motors

        Triclin S.†, Inoue D.†​, Gaillard J., Htet Z. M., DeSantis M. E., Portran D., Derivery E., Aumeier C., Schaedel L., John K., Leterrier C., Reck-Peterson S. L., Blanchoin L.* & Théry M.* (†Contribution equal)

        Nature Materials 2021, 20,883-891

        Mechanical stimulation‐induced orientation of gliding microtubules in confined microwells

        Inoue, D.; Kabir, A. M. R.; Tokuraku, K.; Sada, K.; Kakugo, A.

        Advanced Materials Interfaces 2020, 7, 1902013

        Adaptation of patterns of motile filaments under dynamic boundary conditions

        Inoue, D.; Gutmann, G.; Nitta, T.; Kabir, A. M. R.; Konagaya, A.; Tokuraku, K.; Sada, K.; Hess, H.; Kakugo, A.

        ACS Nano 2019, 13, 12452-12460

        Actin filaments regulate microtubule growth at the centrosome

        Inoue, D. †; Obino, D.†; Farina, F.; Gaillard, J.; Guerin, C.; Blanchoin, L.*; Lennon-Duménil, A. M.*; Théry, M.*

        The EMBO Journal 2019, e99630

        Are microtubules tension sensors?

        Hamant*, O.; Inoue, D.; Bouchez, D.; Dumais, J.; Mjolsness, E.

        Nature Communications 2019, 10, 2369.

        Construction of artificial cilia from microtubules and kinesins through a designed bottom-up approach

        Sasaki, R.; Kabir, A. M. R.; Inoue, D.; Anan, S.; Kimura, A. P., Konagaya, A.; Sada, K. and Kakugo, A.*

        Nanoscale 2018,10, 6323-6332

        DNA-assisted swarm control in a biomolecular motor system

        Keya, J.; Suzuki, R.; Kabir, A. M. R.; Inoue, D.; Asanuma, H.; Sada, K.; Hess, H.*; Kuzuya, A.*; Kakugo, A.*

        Nature Communications 2018, 9, 453

        Depletion force induced collective motion of microtubules driven by kinesin

        Inoue, D.; Mahemuti, B.; Kabir, A. M. R.; Farhana, T. I.; Tokuraku, K.; Sada, K.; Konagaya, A.; Kakugo, A.*

        Nanoscale 2015, 7, 18054-18061

        High-resolution imaging of a single gliding protofilament of tubulins by HS-AFM

        Keya, J. J.†; Inoue, D.†; Suzuki, Y.; Kozai, T.; Ishikuro, D.; Kodera, N.; Uchihashi, T.; Kabir, A. M. R.; Endo, M.; Sada, K.; Kakugo, A.* (†Contribution equal)

        Scientific Reports 2017, 7, 6166

        Sensing surface mechanical deformation using active probes driven by motor proteins

        Inoue, D.; Nitta, T.; Kabir, A. M. R.; Sada, K.; Gong, J.P.; Konagaya, A.; Kakugo, A.*

        Nature Communications 2016, 7, 12557

        Other publications are available here

      • Free Materials for BioArt

        Anyone can use those materials for free. But please don't redistribute these items without modification.

      • Member

        Daisuke Inoue, (Lab PI)

        Assistant Professor

        CV

      • Contact

        Kyushu University, Ohashi campus
        Room 605, Building 3, Shiobaru 4-9-1, Minami-Ku, Fukuoka, 815-8540, Japan
        (+81) 92-553-4431
        (+81) 92-553-4431
        dinoue1@design.kyushu-u.ac.jp
        Submit
      • Related labs

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