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CytoArchitec lab

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    • Home
    • Self-Organization
    • Basic technologies
    • Art gallery
    • Cover Gallery
    • ギャラリー
    • Selected papers
    • Free Materials
    • Member
    • Contact
    • ソーシャルフィード
    • Related labs

    CytoArchitec lab

    • Home
    • Self-Organization
    • Basic technologies
    • Art gallery
    • Cover Gallery
    • ギャラリー
    • Selected papers
    • Free Materials
    • Member
    • Contact
    • ソーシャルフィード
    • Related labs
    • …  
      • Home
      • Self-Organization
      • Basic technologies
      • Art gallery
      • Cover Gallery
      • ギャラリー
      • Selected papers
      • Free Materials
      • Member
      • Contact
      • ソーシャルフィード
      • Related labs
      • Home
      • Self-Organization
      • Basic technologies
      • Art gallery
      • Cover Gallery
      • ギャラリー
      • Selected papers
      • Free Materials
      • Member
      • Contact
      • ソーシャルフィード
      • Related labs
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        • Kyushu University, Faculty of Design

          Cytoskeletal Architecture

          and

          Bio-Self-Assembly lab

        • Design inspired by self-organization in biosystem

          Self-organization is a process in which local interaction between components of a system spontaneously produce ordered structures and fascinating patterns which exhibit emergent functions in the absence of a professional designer. This is a common assembly process in a biosystem and can be co-opted by scientists and designers based on different construction principles and logics of design. Since self-organization grants several advantages to the system including robustness, flexibility and adaptability to the surrounding environment, innovations based on this self-organization may provide a unique avenue for designers and inventors.

          Biomaterials: Cytoskeletons & Motor proteins

          Biophysics, Micro/Nanotechnology

          The study of self-organization in a biosystem, a system comprised of skeletons in cells so-called as cytoskeleton (microtubules and actin) and its related motor proteins, provides one with unique tools and design principles not seen in other systems. The biosystem is one of the best candidates for innovation since they autonomously form various structures, and determine the morphology of the cell wherein they lie. This allows a designer with the ability to innovate with these self-assembling structures, potentially bringing this microscopic design into the macroscopic world. We are studying it using the reconstituted system of cytoskeleton combining with micro/nanotechnologies.

          Artificial materials

          Interior, Architecture design

          To explore potential applications of self-organization, our other challenge is to develop artificial systems organized through self-organization at human scales inspired by cytoskeletons.

        • Basic Equipments & technologies

          Nikon Ti2-E,
          Epi-fluorescence microscope

          Fluorescence microscopy imaging and Label-free imaging with interference reflection microscopy (IRM)

          Formlabs Form3,

          3D printer

          3D print at high resolution
          (0.025 mm) using Low Force Stereolithography (LFS)

        • Cover art & BIOART Gallery

        • a
        • Toilet paper indicates actin filaments polymerizing at cell front. Smou wrestler is myosin.
          ZIgzag pattern of gliding microtubules formed under cyclic stretching
          Active nematic of taxol stabilized microtubules polymerized by GTP
          RIng-shaped microtubule assemblies
          Gliding microtubules over kinesin coated surface observed by IRM
          Steampunk Molecular Chaperone, prototype
          Steampunk Molecular Chaperone, prototype
          Motility assay of 3D printed Steampunk Dynein along tubulin protofilament
          3D printing by using Silk Worm
        • Selected Papers

          Self-repair protects microtubules from destruction by molecular motors

          Triclin S.†, Inoue D.†​, Gaillard J., Htet Z. M., DeSantis M. E., Portran D., Derivery E., Aumeier C., Schaedel L., John K., Leterrier C., Reck-Peterson S. L., Blanchoin L.* & Théry M.* (†Contribution equal)

          Nature Materials 2021

          Mechanical stimulation‐induced orientation of gliding microtubules in confined microwells

          Inoue, D.; Kabir, A. M. R.; Tokuraku, K.; Sada, K.; Kakugo, A.

          Advanced Materials Interfaces 2020

          Adaptation of patterns of motile filaments under dynamic boundary conditions

          Inoue, D.; Gutmann, G.; Nitta, T.; Kabir, A. M. R.; Konagaya, A.; Tokuraku, K.; Sada, K.; Hess, H.; Kakugo, A.

          ACS Nano 2019, 13, 12452-12460

          Actin filaments regulate microtubule growth at the centrosome

          Inoue, D. †; Obino, D.†; Farina, F.; Gaillard, J.; Guerin, C.; Blanchoin, L.*; Lennon-Duménil, A. M.*; Théry, M.*

          The EMBO Journal 2019, e99630

          Are microtubules tension sensors?

          Hamant*, O.; Inoue, D.; Bouchez, D.; Dumais, J.; Mjolsness, E.

          Nature Communications 2019, 10, 2369.

          Construction of artificial cilia from microtubules and kinesins through a designed bottom-up approach

          Sasaki, R.; Kabir, A. M. R.; Inoue, D.; Anan, S.; Kimura, A. P., Konagaya, A.; Sada, K. and Kakugo, A.*

          Nanoscale 2018,10, 6323-6332

          Sensing surface mechanical deformation using active probes driven by motor proteins

          Inoue, D.; Nitta, T.; Kabir, A. M. R.; Sada, K.; Gong, J.P.; Konagaya, A.; Kakugo, A.*

          Nature Communications 2016, 7, 12557

          DNA-assisted swarm control in a biomolecular motor system

          Keya, J.; Suzuki, R.; Kabir, A. M. R.; Inoue, D.; Asanuma, H.; Sada, K.; Hess, H.*; Kuzuya, A.*; Kakugo, A.*

          Nature Communications 2018, 9, 453

          Depletion force induced collective motion of microtubules driven by kinesin

          Inoue, D.; Mahemuti, B.; Kabir, A. M. R.; Farhana, T. I.; Tokuraku, K.; Sada, K.; Konagaya, A.; Kakugo, A.*

          Nanoscale 2015, 7, 18054-18061

          High-resolution imaging of a single gliding protofilament of tubulins by HS-AFM

          Keya, J. J.†; Inoue, D.†; Suzuki, Y.; Kozai, T.; Ishikuro, D.; Kodera, N.; Uchihashi, T.; Kabir, A. M. R.; Endo, M.; Sada, K.; Kakugo, A.* (†Contribution equal)

          Scientific Reports 2017, 7, 6166

          Other publications are available here

        • Free Materials for BioArt

          Anyone can use those materials for free. But please don't redistribute these items without modification.

        • Member

          Daisuke Inoue, (Lab PI)

          Assistant Professor

          CV

        • Contact

          Kyushu University, Ohashi campus
          Room 605, Building 3, Shiobaru 4-9-1, Minami-Ku, Fukuoka, 815-8540, Japan
          (+81) 92-553-4431
          (+81) 92-553-4431
          dinoue1@design.kyushu-u.ac.jp
          Submit
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